Isle of Palms South, Florida Vacation Rentals. Book Beach Rentals, Lake Houses, Condos, Cabins, Villas, and Homes in Isle of Palms South, Florida on RentalSaver.com!

Isle of Palms South Rentals

From $323 per night (USD)
VRBO
Mayo Clinic townhouse in San Pablo with Primary suite located on the 1st floor
Bedrooms:
3
Bathrooms:
3
Sleeps:
6
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 bedroom, 2.5 bathrooms and 2 car garag ...
From $323 per night (USD)
VRBO
$Tranquil Retreat 4BD\/4BTH-Marshviews & Pool SLP 10$
From $705 per night (USD)
Expedia
Tranquil Retreat 4BD\/4BTH-Marshviews & Pool SLP 10
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Welcome to Marsh View: Managed exclusively by Welcome Home Rentals Jax Beach. This property is a 4 bedroom 2 bathroom, p ...
From $705 per night (USD)
Expedia
$Beach Stay w\/ HTD Pool,1mi from Mayo, 3mi to beach$
From $437 per night (USD)
VRBO
Beach Stay w\/ HTD Pool,1mi from Mayo, 3mi to beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Just listed!! 3 bedroom 2 bath pool home. Only 1 mile from Mayo and 3 miles from Jacksonville Beach. The home is all one ...
From $437 per night (USD)
VRBO
From $350 per night (USD)
Expedia
Modern Townhouse minutes from Mayo Clinic UNF & Beach
Bedrooms:
3
Bathrooms:
3
Sleeps:
9
Beautiful townhouse located in the sought after San Pablo area. Fully furnished 3 Bedroom, 2.5 bathroom & car garage. Th ...
From $350 per night (USD)
Expedia
From $2524 per night (USD)
VRBO
HCB 53 Suenos Luxury Yacht
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Want to ride to the sandbar in Style? Fort George, Bird Island, Matanzas Inlet in St. Augustine? This is a NÉW 53 foot ...
From $2524 per night (USD)
VRBO
From $329 per night (USD)
Expedia
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
We believe that you will feel right at home in our bungalow. The backyard will feel like an oasis with a comfortable con ...
From $329 per night (USD)
Expedia
From $317 per night (USD)
VRBO
Your Home Away From Home and 2 miles from The Mayo Clinic and Snowbirds welcomed
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
3 bedroom 2 bath home newly renovated located in a quiet neighborhood 2 miles from Mayo Clinic and a few minutes from th ...
From $317 per night (USD)
VRBO
From $264 per night (USD)
VRBO
New Townhome Lake View, Minutes to Mayo & Beaches
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Just Listed! New Built Townhouse with Lake View in a gated community. 3 bedroom, 2.5 bathrooms with 2 car garage. Master ...
From $264 per night (USD)
VRBO
$Mayo Clinc 1mile from Intercoastal waterfront home w\/pool and Breathtaking Views$
From $384 per night (USD)
VRBO
Mayo Clinc 1mile from Intercoastal waterfront home w\/pool and Breathtaking Views
Bedrooms:
3
Bathrooms:
3
Sleeps:
8
Enjoy amazing water views from EVERY single room in this newly renovated ICW pool home (renovated in March 2016 / Pool N ...
From $384 per night (USD)
VRBO
From $377 per night (USD)
Expedia
Lux Pool Home Close to Mayo & Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
This freshly remodeled open concept, pool home, close to Mayo Clinic and Jax beach is sure to wow you! The home includes ...
From $377 per night (USD)
Expedia
From $530 per night (USD)
VRBO
Fancy private pool home in Jax beach
Bedrooms:
2
Bathrooms:
4
Sleeps:
10
Have fun with the whole family at this stylish place. This house offers a relaxing feel for family and friends vacation ...
From $530 per night (USD)
VRBO
From $487 per night (USD)
Expedia
4BR Family Getaway Heated Pool 1 Level Near Mayo
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Experience tranquility at Osprey’s Rest, a pet-friendly beach house in Jacksonville Beach’s serene Isle of Palms neighbo ...
From $487 per night (USD)
Expedia
From $229 per night (USD)
VRBO
The Retreat close to Mayo Clinic!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Book with confidence with an experienced host! The Retreat is a fully renovated 3 bedroom/2 bathroom house. Guests are ...
From $229 per night (USD)
VRBO
From $117 per night (USD)
VRBO
The Petite Retreat - Walk to Mayo Clinic!
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
The Petite Retreat is fully renovated. This cozy studio/In-law suite features: +king bed +ensuite bathroom +full siz ...
From $117 per night (USD)
VRBO
From $244 per night (USD)
VRBO
NEW- The Cove at San Pablo- Across from the Mayo Clinic
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
**NEW** Welcome to the Cove at San Pablo! Come visit Jax and relax in our newly renovated and fully furnished with 3 bed ...
From $244 per night (USD)
VRBO
Click For Pricing
Expedia
Luxury Home 2 miles from Mayo
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
This is a beach modern style home. Located in a quiet neighborhood off the main street close to the beach (3.5miles) and ...
Click For Pricing
Expedia
$Big Wheelchair Accessible Home Close to Beach\/Mayo with Zen Den and Fenced Yard$
From $328 per night (USD)
VRBO
Big Wheelchair Accessible Home Close to Beach\/Mayo with Zen Den and Fenced Yard
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
*New to VRBO* Welcome to “The Cottage” a recently remodeled spacious and accessible brick ranch home in the heart of Ja ...
From $328 per night (USD)
VRBO
From $345 per night (USD)
Expedia
Mayo Clinic 1.8 miles #2 Your Home Away From Home
Bedrooms:
2
Bathrooms:
3
Sleeps:
5
This 3 /2 is located in the quiet neighborhood of Isle of Palms. It has been fully remodeled inside and out. Extra cle ...
From $345 per night (USD)
Expedia
Click For Pricing
VRBO
5 bedroom home with heated pool and hot tub
Bedrooms:
4
Bathrooms:
5
Sleeps:
10
Beautiful 5 bedroom home with four baths. Heated pool and hot tub with jets enclosed with a cage. Outdoor fireplace and ...
Click For Pricing
VRBO
From $488 per night (USD)
Expedia
Isle of Palms Home-close to Mayo and beach
Bedrooms:
2
Bathrooms:
6
Sleeps:
12
Located on the intracoastal, overlooking the Florida marsh you won't find a more tranquil spot. Sway in the hammock chai ...
From $488 per night (USD)
Expedia
From $470 per night (USD)
VRBO
Manatee House: Private Marsh View Retreat - 1 Mile to Mayo, 5 Miles to Beaches
Bedrooms:
3
Bathrooms:
4
Sleeps:
12
You will love this beautiful and comfortable large marsh view home. Perfect location in a quiet neighborhood within walk ...
From $470 per night (USD)
VRBO
From $207 per night (USD)
VRBO
The Lily House- Flexible Lease Terms, Hospitals and Beaches
Bedrooms:
3
Bathrooms:
3
Sleeps:
8
Come enjoy the sunshine state and plenty of natural light throughout this brand new, fully furnished townhome- minutes t ...
From $207 per night (USD)
VRBO
$Beachy Bungalow: 3BR Home w\/ Billiards\/grill!$
From $333 per night (USD)
VRBO
Beachy Bungalow: 3BR Home w\/ Billiards\/grill!
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
This cozy 1-story, 3 bedroom home is the perfect place to relax and enjoy all that Jacksonville has to offer. Located in ...
From $333 per night (USD)
VRBO
$Brockway · Cozy JAX Beach Home: Close to Beach\/Mayo\/UNF$
From $177 per night (USD)
Expedia
Brockway · Cozy JAX Beach Home: Close to Beach\/Mayo\/UNF
Bedrooms:
1
Bathrooms:
3
Sleeps:
4
Summary: Entire cozy, relaxing, and peaceful home. Queen bed in the master bedroom and expandable queen daybed in the gu ...
From $177 per night (USD)
Expedia
From $233 per night (USD)
VRBO
Seaside Oasis ~ Jacksonville Beach
Bedrooms:
2
Bathrooms:
2
Sleeps:
6
Seaside Oasis is a beachside 2 bedroom and 2 bathroom unit in Jacksonville Beach. ONLY a 7 minute drive from the beach a ...
From $233 per night (USD)
VRBO
$Waterfront Jacksonville Retreat w\/ Boat Dock!$
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Expedia
Waterfront Jacksonville Retreat w\/ Boat Dock!
Bedrooms:
3
Bathrooms:
5
Sleeps:
8
Located in the vibrant city of Jacksonville, this 4-bedroom, 3-bath vacation rental is the ideal base for exploring all ...
Click For Pricing
Expedia
From $262 per night (USD)
VRBO
Amazing New MAYO King Suite
Bedrooms:
2
Bathrooms:
1
Sleeps:
3
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $262 per night (USD)
VRBO
$Private in-law suite with full kitchen, washer\/dryer, & central AC$
From $232 per night (USD)
Expedia
Private in-law suite with full kitchen, washer\/dryer, & central AC
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
By the Beach - In-Law Suite Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply e ...
From $232 per night (USD)
Expedia
$Quiet home on a cul-de-sac with screened patio, W\/D, & central AC$
From $292 per night (USD)
VRBO
Quiet home on a cul-de-sac with screened patio, W\/D, & central AC
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
By the Beach - Main Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply enter you ...
From $292 per night (USD)
VRBO
$Renovated home + in-law suite near the beach with patio, 2 kitchens, AC, & W\/Ds$
From $482 per night (USD)
Expedia
Renovated home + in-law suite near the beach with patio, 2 kitchens, AC, & W\/Ds
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
By the Beach - Full Property Our calendar is updated in real-time & our nightly rates are accurately displayed. Simply ...
From $482 per night (USD)
Expedia
From $234 per night (USD)
VRBO
Pablo Pointe- Single Family Home directly across from the Mayo Clinic
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
We invite you to stay at Pablo Pointe, our new fully renovated family ranch home. Ideal for families and/or patients vis ...
From $234 per night (USD)
VRBO
From $214 per night (USD)
Expedia
5 STAR Upscale King Suite 1 Min to Mayo Clinic!
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
Beautiful "NEW" Gated Suite near MAYO CLINIC! Elevator included. Brand new construction! Designer furnished. Spacious Su ...
From $214 per night (USD)
Expedia
From $270 per night (USD)
VRBO
Beautiful Coastal Home near Mayo Clinic. Pet Friendly!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Come and relax at this impeccably clean and cozy coastal home less than 3 minutes from the Mayo Clinic Jacksonville, 7 m ...
From $270 per night (USD)
VRBO
From $131 per night (USD)
VRBO
Cozy Home Near Mayo & Beaches. Dog-friendly!
Bedrooms:
2
Bathrooms:
2
Sleeps:
4
Private home located in the heart of Jacksonville and close to everything! Centrally located off Beach Blvd, there are e ...
From $131 per night (USD)
VRBO
$Fun 5 Star Hot Tub\/Beaches getaway Near MAYO!$
From $324 per night (USD)
VRBO
Fun 5 Star Hot Tub\/Beaches getaway Near MAYO!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Private quiet 3 Bedroom Home 1300 Sq. Ft. Dedicated workspace and fast WIFI. 3 TVs with Netflix, Hulu, ROKU. Just 5 min ...
From $324 per night (USD)
VRBO
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Expedia
Waterfront Oasis - 5 bedrooms, private pool and 2 docks
Bedrooms:
5
Bathrooms:
5
Sleeps:
10
Discover the epitome of luxury living at the "Chateau Coquina"—a haven that seamlessly combines opulence with the allure ...
Click For Pricing
Expedia
From $552 per night (USD)
VRBO
Tres Palmas!Renovated Pool Home Near Mayo & Beach!
Bedrooms:
2
Bathrooms:
4
Sleeps:
6
Comfort, location, and calm! From the moment you arrive at Las Palmas you will feel that the home has been designed with ...
From $552 per night (USD)
VRBO
From $210 per night (USD)
Expedia
Minutes away from Mayo Clinic, jax Beach, UNF, Ponte Vedra Beach, and PGA & TPC.
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Fully-Furnished 3 bedroom 2 bathroom, quite neighborhood, higher ceiling in the living area. Little storage in the back ...
From $210 per night (USD)
Expedia
From $222 per night (USD)
VRBO
North East Florida Retreat
Bedrooms:
2
Bathrooms:
4
Sleeps:
6
Fabulous beach blvd townhome- with backyard sun room, fire pit, pool table, dart board- something for the whole family! ...
From $222 per night (USD)
VRBO
From $365 per night (USD)
Expedia
Be A Nomad | Spacious 4 BR Close to Mayo & Beaches
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Relax and unwind in a beachy-style bungalow with a short 8-minute drive to the ocean! Nearby to Mayo Clinic and local re ...
From $365 per night (USD)
Expedia
From $227 per night (USD)
VRBO
Be A Nomad | Spacious 1 King BR close Beach & Mayo
Bedrooms:
1
Bathrooms:
1
Sleeps:
2
Take it easy at this unique and tranquil getaway. Private space with brand new furniture. Comfortable and cozy with a p ...
From $227 per night (USD)
VRBO
From $691 per night (USD)
Expedia
Be A Nomad | Spacious Home close to Mayo & Beaches
Bedrooms:
3
Bathrooms:
5
Sleeps:
10
Beachy Bungalow: 8 min to Ocean! Mayo Clinic is nearby. Cozy bedrooms, private deck, and brand-new furniture. Your coast ...
From $691 per night (USD)
Expedia
$1 mile from MAYO CLINIC, 3 miles to the beach! 3 beds\/2 bath fully furnished!$
From $164 per night (USD)
VRBO
1 mile from MAYO CLINIC, 3 miles to the beach! 3 beds\/2 bath fully furnished!
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Nestled in a prime location near the serene beaches and renowned MAYO CLINIC. This FULLY FURNISHED vacation rental offer ...
From $164 per night (USD)
VRBO
From $248 per night (USD)
Expedia
Charming 3-bedroom house in Jacksonville
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Your home away from home in Jacksonville with 3 bedrooms, including 2 king beds and 1 twin bed. This amazing house offer ...
From $248 per night (USD)
Expedia
From $374 per night (USD)
VRBO
Spacious 4-bedroom house in enchanting Jacksonville with WiFi, AC
Bedrooms:
3
Bathrooms:
4
Sleeps:
8
Your home away from home in Jacksonville with 4 lovely bedrooms. Each room is thoughtfully furnished with 1 king bed, 2 ...
From $374 per night (USD)
VRBO
From $417 per night (USD)
Expedia
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Bedrooms:
2
Bathrooms:
3
Sleeps:
8
Make yourself at home in this charming 3-bedroom, 2 bathroom Jacksonville Beach retreat. With a king bed, full bed, and ...
From $417 per night (USD)
Expedia
From $358 per night (USD)
VRBO
1min To Mayo Clinic Luxury Suite
Bedrooms:
2
Bathrooms:
2
Sleeps:
6
ELITE MAYO CLINIC LUXURY RETREAT | 5 MIN TO BEACH Experience Jacksonville's finest! Steps from Mayo Clinic in prestigio ...
From $358 per night (USD)
VRBO
$Ideal for Mayo Clinic Visitors: 3 Spacious Suites w\/ Kitchen and Pool Access$
From $735 per night (USD)
VRBO
Ideal for Mayo Clinic Visitors: 3 Spacious Suites w\/ Kitchen and Pool Access
Bedrooms:
3
Bathrooms:
6
Sleeps:
12
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $735 per night (USD)
VRBO
$Cozy Suite w\/ Kitchen, Heated Pool, & Free Shuttle to Mayo Clinic – Free Parking$
From $245 per night (USD)
VRBO
Cozy Suite w\/ Kitchen, Heated Pool, & Free Shuttle to Mayo Clinic – Free Parking
Bedrooms:
1
Bathrooms:
2
Sleeps:
4
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $245 per night (USD)
VRBO
$2 Spacious Suites w\/ Kitchen, Free Breakfast, and Heated Pool Near Mayo Clinic$
From $490 per night (USD)
VRBO
2 Spacious Suites w\/ Kitchen, Free Breakfast, and Heated Pool Near Mayo Clinic
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $490 per night (USD)
VRBO
$Spacious Room w\/ Full Kitchen, Free Hot Breakfast & Free Shuttle to Mayo Clinic$
From $232 per night (USD)
VRBO
Spacious Room w\/ Full Kitchen, Free Hot Breakfast & Free Shuttle to Mayo Clinic
Bedrooms:
1
Bathrooms:
2
Sleeps:
2
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $232 per night (USD)
VRBO
$4 Comfort-Focused Suites w\/ Kitchen, Heated Pool Access & Mayo Clinic Shuttle$
From $981 per night (USD)
VRBO
4 Comfort-Focused Suites w\/ Kitchen, Heated Pool Access & Mayo Clinic Shuttle
Bedrooms:
4
Bathrooms:
8
Sleeps:
16
With easy access to Highway 202, we're conveniently located near Mayo Clinic, east of Jacksonville. Explore the city: 3 ...
From $981 per night (USD)
VRBO
Click For Pricing
Expedia
Tranquil estate with AC in Jacksonville Beach - 3 bedrooms
Bedrooms:
2
Bathrooms:
3
Sleeps:
6
Consider this estate your home away from home while you visit Jacksonville Beach. With 3 bedrooms and 2 bathrooms, this ...
Click For Pricing
Expedia
From $359 per night (USD)
Expedia
Turquoise Oasis I Family & Dog Friendly I Saltwater Pool I Firepits
Bedrooms:
3
Bathrooms:
3
Sleeps:
6
Welcome to the Turquoise Oasis! This charming 3-bedroom, 2.5-bath home features a first-floor primary suite, a sparkling ...
From $359 per night (USD)
Expedia
From $555 per night (USD)
VRBO
Spacious 4-bedroom building in peaceful Jacksonville with AC, WiFi, outdoor gym
Bedrooms:
2
Bathrooms:
4
Sleeps:
8
Escape to this building in picturesque Jacksonville. This adorable property boasts 4 bedrooms, including 1 king bed, 2 q ...
From $555 per night (USD)
VRBO
From $423 per night (USD)
Expedia
The SMV Palm Estate with Pool
Bedrooms:
3
Bathrooms:
4
Sleeps:
10
Unwind by the sparkling private pool, practice your swing on the putting green, or sip a drink at the outdoor bar and gr ...
From $423 per night (USD)
Expedia

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Isle of Palms South Rentals

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Results: 56 Rentals